| DETROIT LIONS | |||
| Pos. | Player | Injury | Status |
| WR | Dennis Northcutt | Groin | Questionable |
| WR | Calvin Johnson | Knee | Probable |
| C | Dominic Raiola | Knee | Probable |
| DE | Dewayne White | Toe | Probable |
| DT | Joe Cohen | Knee | Questionable |
| DT | Grady Jackson | Knee | Probable |
| LB | Larry Foote | Foot | Questionable |
| LB | Vinny Ciurciu | Ankle | Questionable |
| CB | Phillip Buchanon | Shoulder | Out |
| S | Louis Delmas | Ankle | Questionable |
| LS | Don Muhlbach | Concussion | Probable |
| SAN FRANCISCO 49ERS | |||
| Pos. | Player | Injury | Status |
| RB | Glen Coffee | Hamstring | Doubtful |
| RB | Michael Robinson | Shoulder | Probable |
| FB | Moran Norris | Toe | Probable |
| WR | Isaac Bruce | Ankle | Doubtful |
| OT | Joe Staley | Knee | Probable |
| LB | Takeo Spikes | Hamstring | Probable |
| CB | Nate Clements | Shoulder | Out |
| CB | Marcus Hudson | Back | Probable |
| CB | Shawntae Spencer | Ankle | Probable |
| K | Joe Nedney | Left Hamstring | Out |
| NFL INJURY REPORT GUIDE | |||
| Status | Definition | ||
| Probable | 75% chance that the player will play in the game | ||
| Questionable | 50% chance that the player will play in the game | ||
| Doubtful | 25% chance that the player will play in the game | ||
| Out | 0% chance that the player will play in the game | ||
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