A big reason why Detroit Lions running back Jahvid Best considers himself a matchup nightmare for opposing defenses is because he often gets put in one-on-one situations with linebackers. This happens so often because the Lions have so many weapons on offense.
This particular topic was recently the focus of a piece by CBS Sports' Pat Kirwan. He took a look at which teams in the NFL have the best "triple threat" in terms of matchups. Here's his basis for the rankings:
Teams with one or two "matchup" players can be contained, keeping scoring down. When an offense adds that third threat, defenses must roll coverage to an elite wide receiver, have a linebacker carry the tight end to the safety and bracket a running back with two underneath players. It's just not doable because it requires six defenders players to handle three offensive players. That leaves only five defenders for the other eight offensive players.
Kirwan ranked the Lions' "triple threat" of Calvin Johnson, Brandon Pettigrew and Best fifth in the NFL. I was thinking it might include Titus Young or Nate Burleson, but Kirwan went with a wide receiver, tight end, running back model. The fact that you could pick a few other guys to plug into the Lions' "triple threat" shows just how many weapons they have.
You can check out Kirwan's top 10 here.