The Detroit Lions are going out west to face the San Francisco 49ers in their second game of the season. In this edition of the podcast, the Two Bros talk about how the Lions defense matches up against the 49ers offense. Evilsmurf and Tufflynx discuss topics such as how the Lions will have difficulty with the 49ers run game, how Randy Moss is fitting in the 49ers offense, how the Detroit secondary is shaping up for week two, and much more. Join the Two Bros to get a detailed preview of every game the Lions play this season.