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| Position | Player | Injury | Status |
| DT | Marcus Bell | Hand | Out |
| CB | Fernando Bryant | Concussion | Out |
| G | Blaine Saipaia | Chest | Out/IR |
| G | Ross Verba | Groin | Out |
| LB | Teddy Lehman | Hamstring | Questionable |
| TE | Marcus Pollard | Hamstring | Questionable |
| WR | Eddie Drummond | Hip | Probable |
| The following players missed a portion of Thursday's practice: DT Marcus Bell, CB Fernando Bryant, LB Teddy Lehman, TE Marcus Pollard, G Blaine Saipaia and G Ross Verba. | |||
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| Position | Player | Injury | Status |
| DE | Michael Montgomery | Knee | Out |
| S | Atari Bigby | Hamstring | Questionable |
| WR | Donald Driver | Shoulder | Questionable |
| TE | David Martin | Ribs | Questionable |
| WR | Ruvell Martin | Chest | Questionable |
| T | Mark Tauscher | Groin | Questionable |
| LB | Ben Taylor | Hamstring | Questionable |
| RB | Ahman Green | Knee | Probable |
| C | Scott Wells | Illness | Probable |
| CB | Charles Woodson | Shoulder | Probable |
| The following players missed a portion of Thursday's practice: S Atari Bigby, WR Ruvell Martin, DE Michael Montgomery and CB Charles Woodson. | |||
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| Status | Definition | ||
| Probable | 75% chance that the player will play in the game | ||
| Questionable | 50% chance that the player will play in the game | ||
| Doubtful | 25% chance that the player will play in the game | ||
| Out | 0% chance that the player will play in the game | ||