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| Position | Player | Injury | Status |
| RB | T.J. Duckett | Ankle | Questionable |
| RB | Brian Calhoun | Knee | Out for Season |
| WR | Calvin Johnson | Back | Questionable |
| DE | Corey Smith | Groin | Questionable |
| DE | Kalimba Edwards | Ankle | Questionable |
| LB | Alex Lewis | Hamstring | Out |
| LB | Anthony Cannon | Quad | Doubtful |
| CB | Keith Smith | Ankle | Out |
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| Position | Player | Injury | Status |
| RB | Clinton Portis | Knee | Probable |
| FB | Mike Sellers | Heel | Probable |
| WR | Santana Moss | Groin | Doubtful |
| WR | Brandon Lloyd | Shin | Probable |
| OG | Randy Thomas | Triceps | Out |
| CB | Fred Smoot | Hamstring | Probable |
| S | Sean Taylor | Knee | Probable |
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| Status | Definition | ||
| Probable | 75% chance that the player will play in the game | ||
| Questionable | 50% chance that the player will play in the game | ||
| Doubtful | 25% chance that the player will play in the game | ||
| Out | 0% chance that the player will play in the game | ||