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| Position | Player | Injury | Status |
| QB | Jon Kitna | Back | Probable |
| FB | Jon Bradley | Ankle | Probable |
| WR | Calvin Johnson | Back | Probable |
| OT | Jonathan Scott | Hand | Out |
| DE | Dewayne White | Elbow | Doubtful |
| DE | Ikaika Alama-Francis | Hamstring | Questionable |
| CB | Fernando Bryant | Foot | Probable |
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| Position | Player | Injury | Status |
| RB | Derrick Ward | Ankle/Groin | Out |
| WR | Steve Smith | Hamstring | Out |
| WR | Plaxico Burress | Ankle | Questionable |
| LB | Antonio Pierce | Concussion | Questionable |
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| Status | Definition | ||
| Probable | 75% chance that the player will play in the game | ||
| Questionable | 50% chance that the player will play in the game | ||
| Doubtful | 25% chance that the player will play in the game | ||
| Out | 0% chance that the player will play in the game | ||