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| Position | Player | Injury | Status |
| WR | Calvin Johnson | Back | Probable |
| OT | George Foster | Ankle | Probable |
| DE | Kalimba Edwards | Knee | Questionable |
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| Position | Player | Injury | Status |
| RB | Travis Henry | Ribs | Probable |
| WR | Brandon Stokley | Hamstring | Probable |
| WR | Javon Walker | Knee | Out |
| OG | Montrae Holland | Shoulder | Probable |
| DE | Jarvis Moss | Leg | Out |
| DT | Antwon Burton | Ankle | Probable |
| LB | D.J. Williams | Shoulder | Probable |
| CB | Champ Bailey | Quadriceps | Probable |
| S | John Lynch | Neck | Questionable |
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| Status | Definition | ||
| Probable | 75% chance that the player will play in the game | ||
| Questionable | 50% chance that the player will play in the game | ||
| Doubtful | 25% chance that the player will play in the game | ||
| Out | 0% chance that the player will play in the game | ||