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| Position | Player | Injury | Status |
| WR | Roy Williams | Knee | Out |
| WR | Troy Walters | Concussion | Out |
| TE | Casey FitzSimmons | Shin | Probable |
| DT | Shaun Rogers | Knee | Probable |
| S | Kenoy Kennedy | Knee | Probable |
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| Position | Player | Injury | Status |
| QB | Philip Rivers | Knee | Questionable |
| FB | Lorenzo Neal | Fibula | Out |
| WR | Buster Davis | Achilles | Probable |
| TE | Antonio Gates | Back | Questionable |
| OG | Mike Goff | Foot | Probable |
| DE | Luis Castillo | Ankle | Doubtful |
| DT | Jamal Williams | Ankle | Questionable |
| LB | Shawne Merriman | Knee | Out |
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| Status | Definition | ||
| Probable | 75% chance that the player will play in the game | ||
| Questionable | 50% chance that the player will play in the game | ||
| Doubtful | 25% chance that the player will play in the game | ||
| Out | 0% chance that the player will play in the game | ||