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| Position | Player | Injury | Status |
| RB | T.J. Duckett | Ankle | Out |
| WR | Calvin Johnson | Back | Questionable |
| OT | Jeff Backus | Rib | Questionable |
| OG | Damien Woody | Rib | Questionable |
| DE | Kalimba Edwards | Ankle | Questionable |
| LB | Alex Lewis | Hamstring | Out |
| LB | Anthony Cannon | Quad | Out |
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| Position | Player | Injury | Status |
| RB | Adrian Peterson | Calf | Probable |
| OT | Fred Miller | Knee | Questionable |
| OG | Ruben Brown | Ankle | Questionable |
| DE | Adewale Ogunleye | Hip | Probable |
| DT | Darwin Walker | Knee | Probable |
| DT | Tommie Harris | Knee | Questionable |
| LB | Brian Urlacher | Back | Probable |
| LB | Lance Briggs | Hamstring | Questionable |
| CB | Charles Tillman | Ankle | Questionable |
| CB | Nathan Vasher | Groin | Doubtful |
| S | Adam Archuleta | Hand | Questionable |
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| Status | Definition | ||
| Probable | 75% chance that the player will play in the game | ||
| Questionable | 50% chance that the player will play in the game | ||
| Doubtful | 25% chance that the player will play in the game | ||
| Out | 0% chance that the player will play in the game | ||