| DETROIT LIONS | |||
| Pos. | Player | Injury | Status |
| QB | Daunte Culpepper | Right Shoulder | Doubtful |
| QB | Dan Orlovsky | Hand | Probable |
| RB | Kevin Smith | Ankle | Questionable |
| WR | Calvin Johnson | Hand | Questionable |
| WR | Shaun McDonald | Ankle | Out |
| DE | Dewayne White | Calf | Questionable |
| DT | Cory Redding | Ankle | Out (IR) |
| DT | Chuck Darby | Calf | Probable |
| CB | Leigh Bodden | Groin | Questionable |
| CB | Keith Smith | Groin | Questionable |
| INDIANAPOLIS COLTS | |||
| Pos. | Player | Injury | Status |
| RB | Joseph Addai | Shoulder | Questionable |
| RB | Chad Simpson | Ankle | Questionable |
| WR | Pierre Garcon | Non-injury | Questionable |
| OT | Tony Ugoh | Knee | Questionable |
| DE | Keyunta Dawson | Hamstring | Questionable |
| DT | Eric Foster | Neck | Questionable |
| LB | Gary Brackett | Fibula | Out |
| LB | Tyjuan Hagler | Knee | Out |
| LB | Freddy Keiaho | Abdomen | Questionable |
| S | Bob Sanders | Knee | Questionable |
| NFL INJURY REPORT GUIDE | |||
| Status | Definition | ||
| Probable | 75% chance that the player will play in the game | ||
| Questionable | 50% chance that the player will play in the game | ||
| Doubtful | 25% chance that the player will play in the game | ||
| Out | 0% chance that the player will play in the game | ||