| DETROIT LIONS | |||
| Pos. | Player | Injury | Status |
| QB | Drew Stanton | Right Thumb | Probable |
| DE | Corey Smith | Hamstring | Questionable |
| DT | Cory Redding | Ankle | Questionable |
| DT | Langston Moore | Groin | Probable |
| LB | Jordon Dizon | Neck | Questionable |
| S | Gerald Alexander | Concussion | Probable |
| SAN FRANCISCO 49ERS | |||
| Pos. | Player | Injury | Status |
| OT | Jonas Jennings | Shoulder | Out |
| CB | Shawntae Spencer | Knee | Out |
| CB | Donald Strickland | Knee | Questionable |
| NFL INJURY REPORT GUIDE | |||
| Status | Definition | ||
| Probable | 75% chance that the player will play in the game | ||
| Questionable | 50% chance that the player will play in the game | ||
| Doubtful | 25% chance that the player will play in the game | ||
| Out | 0% chance that the player will play in the game | ||