| DETROIT LIONS | |||
| Pos. | Player | Injury | Status |
| QB | Matthew Stafford | Knee | Questionable |
| RB | Kevin Smith | Shoulder | Probable |
| WR | Calvin Johnson | Thigh | Probable |
| TE | Brandon Pettigrew | Hamstring | Probable |
| OT | Gosder Cherilus | Shoulder | Questionable |
| DE | Dewayne White | Hamstring | Out |
| DE | Cliff Avril | Hamstring | Questionable |
| DT | Sammie Hill | Ankle | Out |
| DT | Grady Jackson | Knee | Probable |
| LB | Ernie Sims | Shoulder | Probable |
| S | Ko Simpson | Hamstring | Questionable |
| S | Kalvin Pearson | Quadricep | Questionable |
| PITTSBURGH STEELERS | |||
| Pos. | Player | Injury | Status |
| RB | Willie Parker | Toe | Out |
| TE | David Johnson | Ankle | Questionable |
| OG | Chris Kemoeatu | Ankle | Probable |
| LB | Andre Frazier | Shoulder | Probable |
| S | Troy Polamalu | Knee | Doubtful |
| NFL INJURY REPORT GUIDE | |||
| Status | Definition | ||
| Probable | 75% chance that the player will play in the game | ||
| Questionable | 50% chance that the player will play in the game | ||
| Doubtful | 25% chance that the player will play in the game | ||
| Out | 0% chance that the player will play in the game | ||