(Note: Longest injury report ever.)
| DETROIT LIONS | |||
| Pos. | Player | Injury | Status |
| QB | Matthew Stafford | Knee | Probable |
| FB | Jerome Felton | Ankle | Probable |
| WR | Derrick Williams | Hip | Questionable |
| WR | Calvin Johnson | Hand | Probable |
| DE | Dewayne White | Toe | Questionable |
| DE | Jason Hunter | Knee | Probable |
| DT | Grady Jackson | Knee | Probable |
| DT | Joe Cohen | Ankle | Probable |
| LB | Ernie Sims | Hamstring | Out |
| LB | Zack Follett | Neck | Questionable |
| LB | Jordon Dizon | Neck | Probable |
| LB | Larry Foote | Knee | Probable |
| CB | Phillip Buchanon | Knee | Probable |
| S | Kalvin Pearson | Hamstring | Out |
| S | Louis Delmas | Tooth | Probable |
| S | Ko Simpson | Knee | Probable |
| CLEVELAND BROWNS | |||
| Pos. | Player | Injury | Status |
| RB | Jamal Lewis | Ankle | Questionable |
| FB | Lawrence Vickers | Shoulder | Questionable |
| WR | Joshua Cribbs | Neck | Questionable |
| WR | Chansi Stuckey | Calf | Probable |
| TE | Robert Royal | Finger | Probable |
| OT | John St. Clair | Shoulder | Probable |
| OG | Rex Hadnot | Knee | Questionable |
| C | Alex Mack | Wrist | Probable |
| DE | Kenyon Coleman | Groin | Probable |
| DT | Shaun Rogers | Back | Probable |
| LB | David Bowens | Knee | Probable |
| NFL INJURY REPORT GUIDE | |||
| Status | Definition | ||
| Probable | 75% chance that the player will play in the game | ||
| Questionable | 50% chance that the player will play in the game | ||
| Doubtful | 25% chance that the player will play in the game | ||
| Out | 0% chance that the player will play in the game | ||