You can check out the full NFL schedule for the 2010 season here. Below is what the Lions' entire 2010 schedule looks like with time and TV details included.
| Wk. | Date | Opponent | Time (ET) | TV |
| 1 | August 14, 2010 |
at Pittsburgh Steelers |
7:30 PM |
WWJ-TV |
| 2 | August 21, 2010 |
at Denver Broncos |
9:00 PM |
WWJ-TV |
| 3 | August 28, 2010 |
vs. Cleveland Browns |
5:30 PM |
WWJ-TV |
| 4 | September 2, 2010 |
vs. Buffalo Bills |
7:00 PM |
WWJ-TV |
| Wk. | Date | Opponent | Time (ET) | TV |
| 1 | September 12, 2010 |
at Chicago Bears |
1:00 PM |
FOX |
| 2 | September 19, 2010 | vs. Philadelphia Eagles |
1:00 PM | FOX |
| 3 | September 26, 2010 | at Minnesota Vikings |
1:00 PM | FOX |
| 4 | October 3, 2010 | at Green Bay Packers |
1:00 PM | FOX |
| 5 | October 10, 2010 | vs. St. Louis Rams |
1:00 PM | FOX |
| 6 | October 17, 2010 | at New York Giants |
1:00 PM |
FOX |
| 7 | October 24, 2010 | ---BYE WEEK--- | ||
| 8 | October 31, 2010 |
vs. Washington Redskins |
1:00 PM | FOX |
| 9 | November 7, 2010 | vs. New York Jets |
1:00 PM | CBS |
| 10 | November 14, 2010 | at Buffalo Bills | 1:00 PM | FOX |
| 11 | November 21, 2010 | at Dallas Cowboys |
1:00 PM | FOX |
| 12 | November 25, 2010 | vs. New England Patriots* | 12:30 PM |
CBS |
| 13 | December 5, 2010 | vs. Chicago Bears | 1:00 PM | FOX |
| 14 | December 12, 2010 | vs. Green Bay Packers | 1:00 PM | FOX |
| 15 | December 19, 2010 | at Tampa Bay Buccaneers |
1:00 PM | FOX |
| 16 | December 26, 2010 | at Miami Dolphins |
1:00 PM | FOX |
| 17 | January 2, 2011 | vs. Minnesota Vikings | 1:00 PM | FOX |
| *Played on Thanksgiving/Nationally Televised | Flex Scheduling from Weeks 11-17 | ||||