The NFL sent out a press release to officially announce all of the dates and times for the preseason schedule. I'm not exactly sure why since the dates and times for the Lions' preseason schedule have been set since April, but here they are again in case you missed it:
| Wk. | Date | Opponent | Time (ET) | TV |
| 1 | August 14, 2010 |
at Pittsburgh Steelers |
7:30 PM |
WWJ-TV |
| 2 | August 21, 2010 |
at Denver Broncos |
9:00 PM |
WWJ-TV |
| 3 | August 28, 2010 |
vs. Cleveland Browns |
5:30 PM |
WWJ-TV |
| 4 | September 2, 2010 |
vs. Buffalo Bills |
7:00 PM |
WWJ-TV |