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NFL Week 12 expert picks: Lions vs. Bills score predictions

Can the Detroit Lions pull off a huge upset on Thanksgiving or will the Buffalo Bills show that there is still a ways to go for this franchise? Our Thanksgiving Day picks are here:

NFL: Chicago Bears at Detroit Lions Raj Mehta-USA TODAY Sports

I’ve tried to stop myself from even thinking about the Detroit Lions winning their fourth game in a row. A win on Thanksgiving against the Buffalo Bills would be the franchise’s most significant win since at least 2016, possibly even before that. A 5-6 record with the “easiest” part of the schedule would make a postseason run a very real possibility.

But perhaps even more important, it would signify irrefutable progress this franchise has been lacking for a half-decade. Coach Dan Campbell and general manager Brad Holmes have done a lot of popular things in Detroit thus far, but the wins have taken longer than most expected, allowing doubt to creep in.

If the Lions beat the Super Bowl contending Buffalo Bills on Thanksgiving, just about all of that doubt will be erased. It’s a thrilling and addictive thought. The Lions finally being on the right track led by a group of extremely likable people running the team.

Alas, for most of the Pride of Detroit staff, that fantasy feels a bit too good to be true. The Lions may be improving, but the Bills are in the top tier of the NFL right now, and the Lions just aren’t there yet—according to our staff.

Here’s a look at our Week 12 expert picks for Lions vs. Bills, with most of us taking the visiting team.

Kellie Rowe (8-2): 31-20 Bills
Jerry Mallory (6-4): 37-23 Bills
Hamza Baccouche (6-4): 37-28 Bills
Ryan Mathews (6-4): 28-24 Lions
Morgan Cannon (5-5): 35-31 Bills
Kyle Yost (5-5): 31-24 Bills
Jeremy Reisman (5-5): 34-24 Bills
Mike Payton (5-5): 38-25 Lions
John Whiticar (5-5): 33-20 Bills
Erik Schlitt (5-5): 34-27 Bills
Alex Reno (4-6): 30-27 Lions
Chris Perfett (0-0-10): 42-42 Tie

All of our Week 12 picks are coming later in the week, as well as our picks for the other two Thanksgiving Day games.

For now, let’s hear your picks for Lions vs. Bills. Vote in the poll below and share your score predictions in the comment section below.


Who wins?

This poll is closed

  • 52%
    (410 votes)
  • 47%
    (376 votes)
786 votes total Vote Now

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After winning their first NFC North title in 30 years, the Lions have unfinished business this offseason. Stay updated with Jeremy Reisman through Pride of Detroit Direct, our newsletter offering up exclusive analysis. Sign up with NFCNORTH30 to get 30% off after your free trial.