I'm going to get right down to it:
QB Jared Goff could have a huge season and put himself back into the discussion as a top 5 QB.
RB D'Andre Swift could rush for 1200 yards and gather another 500 or more receiving - Pro Bowl season?
TE T J Hockenson is in a contract year, but more importantly it's time to graduate to being a truly elite TE. 90 receptions for 1200 yards and a 10-15 TDs would assure that status and make him Pro Bowl bound!
WR Amon-Ra St Brown seems intent to build on last year and perhaps gather 90 receptions and 1500 yards. Definitely a break-out campaign waiting to happen.
OT Taylor Decker is in his prime and healthy. ALL PRO seems possible with the supporting cast the Lions have on the rest of the OL as well as the potential for gaudy stats for the skill position players.
OC Frank Ragnow seems ready to rumble and re-establish himself as the premier OC. ALL PRO potential here too.
OT Penei Sewell is very good and might make Detroit proud this season with a Pro Bowl nod.
OG Jonah Jackson might feel competitive and want another Pro Bowl selection too, to begin what might be a fantastic career.
DL Alim McNeill would look great at the Pro Bowl, wouldn't he?
DE Aidan Hutchinson might be a great candidate to win Defensive rookie of the year. Perhaps even get a Pro Bowl nod too.
LB Alex Anzalone seems primed to go on the attack, and just might be a great LB!
CB Amani Oruwariye has quietly but ever so efficiently become a stud. Maybe Pro Bowl recognition will come his way.
CB Jeff Okudah has so much potential. Does he breakout this year by simply staying healthy and playing to his potential? I think so!
FS Tracy Walker seems like he is just skimming the surface of his potential. Could this be the year that changes? Pro Bowl bound?
There are other possibilities to emerge too. Jameson Williams likely will need to take some time to fully heal, but watch out for what he might be able to do in 12 or 13 games. D J Chark might develop the chemistry to be the deep threat Goff needs; Chark is capable of a 1000 plus yard receiving season. Hal Vaitai isn't a slouch at OG. He could feel slighted if he isn't given some recognition this year, of course he'll have to earn it. Derrick Barnes seemed to lose steam after getting injured last year. Does he regain that edge and burst on the scene in 2022? Levi Onwuzurike was a disappointment that year because he played injured. Remember he was drafted before McNeill so just maybe he has something he wants to prove this year to make up for lost time.
That's 19 out of 22 starters on offense and defense. I may have overlooked Jack Fox as a Pro Bowl candidate too, on special teams.